TITLE: Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin. SHORT TITLE: Hepcidin-independent anaemia of infection. AUTHORS:
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چکیده
137. Text: 4053. NUMBER OF FIGURES: 4; NR OF TABLES: 2; NR OF REFERENCES: 45. PRIMARY SCIENTIFIC CATEGORY: Red Cells, Iron and Erythropoiesis.
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Hepcidin: inflammation's iron curtain.
Editorial Hepcidin: inflammation's iron curtain Rheumatologists and their patients are the beneficiaries of a recently identified peptide, hepcidin (Table 1). Isolated from human urine and plasma in the year 2000 [1, 2], hepcidin appears to be the long-sought iron-regulatory hormone responsible for the anaemia of chronic disease [3, 4]. It is more than that: it is an acute-phase reactant, respo...
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Background: Pathogenesis of anaemia of chronic disease is multifactorial. It is related with corrupted erythropoietin-dependent erythropoiesis due to C-reactive protein, and pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha. It is also related with decreased red cell survival and impaired iron mobilization. Hepcidin level in iron deficiency anaemia is low than co...
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Iron is essential for all organisms and its availability can control the growth of microorganisms; therefore, we examined the role of iron metabolism in multibacillary (MB) leprosy, focusing on the involvement of hepcidin. Erythrograms, iron metabolism parameters, pro-inflammatory cytokines and urinary hepcidin levels were evaluated in patients with MB and matched control subjects. Hepcidin exp...
متن کاملHepcidin--a well-known iron biomarker with prognostic implications in chronic kidney disease.
Studying hepcidin in humans is en vogue as demonstrated by an increasing number of publications addressing this key hormone of iron homeostasis over the last decade. As a key regulator of iron transport, hepcidin has been clearly implicated in the pathogenesis of anaemia in chronic kidney disease (CKD), but a more complex pathophysiology is beginning to emerge in which altered iron biology cont...
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Hepcidin is an innate immune element which decreases the iron absorption from diet and iron releasing from macrophage cell. In contrast to the chemical iron chelators, there has been limited effort applied to the specific use of hepcidin as a new drug for decreasing the iron overload. Hepcidin is produced in different biological systems. For instance, E-coli is used for human hepcidin expressio...
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تاریخ انتشار 2010